IngentaConnect Male reproductive effect of nickel sulphate in mice

Authors: Pandey R.¹; Kumar R.²; Singh S.P.¹; Saxena D.K.²; Srivastava S.P.²

Source: BioMetals, Volume 12, Number 4, December 1999 , pp. 339-346(8)

Publisher: Springer

Abstract:

Nickel sulphate was administered orally to adult male mice at dose level of 5 and 10 mg/kg body weight (5 days per week) for 35 days. There was no change in body weight. However a significant decrease in absolute and organ-to-body weight ratios of testes, epididymides, seminal vesicles and prostate gland was observed. The sperm abnormality, associated with decrease in sperm motility and sperm count was also observed. Significant alterations in the activities of marker testicular enzymes, viz. sorbitol dehydrogenase (decreases), lactate dehydrogenase (increases) and ggr -glutamyl transpeptidase (increases) associated with histopathological changes in testes, epididymides and seminal vesicles, were also observed. Accumulation of nickel in testes, epididymides and seminal vesicles was also observed. The study reveals that the oral exposure to nickel may affect the histology of testes, epididymides, seminal vesicles and sperms morphology. These testicular and spermatotoxic changes may be responsible for observed male mediated developmental toxic effects.

Keywords: nickel sulphate; enzymes; mice; sperm testis; epididymis; seminal vesicle

Language: English

Document Type: Regular paper

Affiliations: 1: Department of Zoology, Lucknow University, Lucknow-226007, India 2: Industrial Toxicology Resarch Centre, Lucknow-226001, India

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