Improvement of artemisinin production by chitosan in hairy root cultures of Artemisia annua L.

Authors: Putalun, Waraporn; Luealon, Wanwimon; De-Eknamkul, Wanchai; Tanaka, Hiroyuki; Shoyama, Yukihiro

Source: Biotechnology Letters, Volume 29, Number 7, July 2007 , pp. 1143-1146(4)

Publisher: Springer

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Abstract:

Artemisinin production by hairy roots of Artemisia annua L. was increased 6-fold to 1.8 μg mg⁻¹ dry wt over 6 days by adding 150 mg chitosan l⁻¹. The increase was dose-dependent. Similar treatment of hairy roots with methyl jasmonate (0.2 mM) or yeast extract (2 mg ml⁻¹) increased artemisinin production to 1.5 and 0.9 μg mg⁻¹ dry wt, respectively.

Keywords: Artemisia annua L; Artemisinin; Elicitors; Hairy roots

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s10529-007-9368-8

Affiliations: 1: Email: waraporn@kku.ac.th

Publication date: 2007-07-01