Detoxification of amitriptyline by oligochitosan derivatives
Source: Biotechnology Letters, Volume 26, Number 9, May 2004 , pp. 713-716(4)
Abstract:Oligo-chitosans were chemically modified with dinitrophenyl groups for selective and rapid adsorption of amitriptyline by forming - complexes. 1H-NMR was utilized not only for characterization of modified chitosans but also for monitoring the aromatic-aromatic interaction. The variation in the chemical shift of aromatic protons was followed to monitor the aromatic-aromatic interaction. Upfield shift of aromatic protons of dinitrophenyl groups supports aromatic-aromatic interactions with amitriptyline. Drug uptake test by HPLC reveals that dinitrophenyl chitosan particles (12 m) at 0.4 wt% (w/v) in a saline solution (pH 6.9) adsorb 90% amitriptyline within 30 min.
Document Type: Research article
Affiliations: 1: Department of Materials Science and Engineering, University of Florida, Gainesville, FL 32611, USA 2: Department of Materials Science and Engineering, University of Florida, Gainesville, FL 32611, USA firstname.lastname@example.org, Fax: +1-352-846-3355, Email: email@example.com
Publication date: 2004-05-01