Detoxification of amitriptyline by oligochitosan derivatives

Authors: Lee D-W.¹; Baney R.²

Source: Biotechnology Letters, Volume 26, Number 9, May 2004 , pp. 713-716(4)

Publisher: Springer

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Abstract:

Oligo-chitosans were chemically modified with dinitrophenyl groups for selective and rapid adsorption of amitriptyline by forming pgr

complexes. ¹H-NMR was utilized not only for characterization of modified chitosans but also for monitoring the aromatic-aromatic interaction. The variation in the chemical shift of aromatic protons was followed to monitor the aromatic-aromatic interaction. Upfield shift of aromatic protons of dinitrophenyl groups supports aromatic-aromatic interactions with amitriptyline. Drug uptake test by HPLC reveals that dinitrophenyl chitosan particles (1–2 mgr

m) at 0.4 wt% (w/v) in a saline solution (pH 6.9) adsorb 90% amitriptyline within 30 min.

Keywords: amitriptyline; aromatic-aromatic interaction; chemical shift; chitosan; HPLC

Document Type: Research article

DOI: http://dx.doi.org/10.1023/B:BILE.0000024094.16474.35

Affiliations: 1: Department of Materials Science and Engineering, University of Florida, Gainesville, FL 32611, USA 2: Department of Materials Science and Engineering, University of Florida, Gainesville, FL 32611, USA rbane@mse.ufl.edu, Fax: +1-352-846-3355, Email: rbane@mse.ufl.edu

Publication date: 2004-05-01