CTLA4 A49G Polymorphism Shows Significant Association With Glioma Risk in a Chinese Population
Authors: Wu, Qihan1; Zhan, Xiaoying1; Dou, Tonghai2; Chen, Hongyan2; Fan, Weiwei2; Zhou, Keke3; Zhang, Haishi3; Zheng, Hongxia1; Cai, Yanyan1; Zhao, Yao3; Huang, Fengping3; Zhou, Liangfu3; Mao, Ying4; Lu, Daru5
Source: Biochemical Genetics, Volume 49, Numbers 3-4, April 2011 , pp. 190-201(12)
Abstract:Cytotoxic T lymphocyte-associated antigen-4 (CTLA4) A49G is a polymorphism that is extensively studied in various cancers. To investigate whether it is associated with the occurrence of glioma in Chinese patients, we performed a case-control research study with 670 patients and 680 controls. In this group, we found that the genotype at this locus is significantly associated with glioma risk (GG vs. AA: P = 0.045; GG + AG vs. AA: P = 0.013). In some subgroups, G allele carriers are significantly less represented. We also observed significant correlations between the polymorphism genotype and glioma risk in patients with WHO histologic stages. We conclude that CTLA4 A49G might be a potential clinical biomarker for distinguishing persons with a high risk for developing gliomas.
Document Type: Research article
Affiliations: 1: School of Life Science, East China Normal University, Shanghai, 200062, China 2: State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes for Biomedical Sciences, Fudan University, Handan Rd, Shanghai, 200433, China 3: Neurosurgery Department, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Rd, Shanghai, 200040, China 4: Neurosurgery Department, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Rd, Shanghai, 200040, China, Email: email@example.com 5: School of Life Science, East China Normal University, Shanghai, 200062, China, Email: firstname.lastname@example.org
Publication date: 2011-04-01