CTLA4 A49G Polymorphism Shows Significant Association With Glioma Risk in a Chinese Population

Authors: Wu, Qihan¹; Zhan, Xiaoying¹; Dou, Tonghai²; Chen, Hongyan²; Fan, Weiwei²; Zhou, Keke³; Zhang, Haishi³; Zheng, Hongxia¹; Cai, Yanyan¹; Zhao, Yao³; Huang, Fengping³; Zhou, Liangfu³; Mao, Ying⁴; Lu, Daru⁵

Source: Biochemical Genetics, Volume 49, Numbers 3-4, April 2011 , pp. 190-201(12)

Publisher: Springer

Abstract:

Cytotoxic T lymphocyte-associated antigen-4 (CTLA4) A49G is a polymorphism that is extensively studied in various cancers. To investigate whether it is associated with the occurrence of glioma in Chinese patients, we performed a case-control research study with 670 patients and 680 controls. In this group, we found that the genotype at this locus is significantly associated with glioma risk (GG vs. AA: P = 0.045; GG + AG vs. AA: P = 0.013). In some subgroups, G allele carriers are significantly less represented. We also observed significant correlations between the polymorphism genotype and glioma risk in patients with WHO histologic stages. We conclude that CTLA4 A49G might be a potential clinical biomarker for distinguishing persons with a high risk for developing gliomas.

Keywords: CTLA4; Glioma; Polymorphism; Case-control study

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s10528-010-9398-0

Affiliations: 1: School of Life Science, East China Normal University, Shanghai, 200062, China 2: State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes for Biomedical Sciences, Fudan University, Handan Rd, Shanghai, 200433, China 3: Neurosurgery Department, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Rd, Shanghai, 200040, China 4: Neurosurgery Department, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Rd, Shanghai, 200040, China, Email: yingmao168@hotmail.com 5: School of Life Science, East China Normal University, Shanghai, 200062, China, Email: drlu@fudan.edu.cn

Publication date: 2011-04-01

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• In this Subject: Biology ,  Genetics
• By this author: Wu, Qihan ;  Zhan, Xiaoying ;  Dou, Tonghai ;  Chen, Hongyan ;  Fan, Weiwei ;  Zhou, Keke ;  Zhang, Haishi ;  Zheng, Hongxia ;  Cai, Yanyan ;  Zhao, Yao ;  Huang, Fengping ;  Zhou, Liangfu ;  Mao, Ying ;  Lu, Daru

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