Effect of diazepam on anxiety, sexual motivation, and blood testosterone in anxious male mice

Authors: Amikishieva, A.; Semendyaeva, S.

Source: Bulletin of Experimental Biology and Medicine, Volume 140, Number 6, December 2005 , pp. 658-663(6)

Publisher: Springer

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Abstract:

The effects of diazepam on anxious behavior, sexual motivation, and blood level of testosterone in the presence of a female were studied in male mice with elevated anxiety. Diazepam produced an anxiolytic effect in novel environment, but was ineffective during social contacts. The drug potentiated the primary sexual interest, but failed to correct exhaustion of sexual motivation. The drug produced no effect on blood testosterone.

Keywords: diazepam; GABAA-receptors; social stress; anxiety; sexual motivation

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s10517-006-0047-x

Affiliations: 1: Email: amik@bionet.nsc.ru

Publication date: 2005-12-01