Antigenic Differences between apo-B in Native and Circulating Modified Low-Density Lipoproteins

Authors: I. V. Suprun; A. A. Melnichenko; E. V. Yanushevskaya; T. N. Vlasik; I. A. Sobenin; O. M. Panasenko; A. N. Orekhov

Source: Bulletin of Experimental Biology and Medicine, Volume 138, Number 1, July 2004 , pp. 42-44(3)

Publisher: Springer

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Abstract:

The state of apo-B in native and circulating modified low-density lipoproteins was studied by solid-phase enzyme immunoassay. We studied the interaction of these particles with monoclonal antibodies to apo-B of low-density lipoproteins. Native and circulating modified low-density lipoproteins had different affinity for the studied antigens. Our results illustrate conformational changes in apo-B of circulating modified low-density lipoproteins compared to native low-density lipoproteins. These changes probably contribute to increased accumulation of particles in vascular cells and their transformation into foam cells giving way to atherosclerotic vascular lesions.

Keywords: low-density lipoproteins; modified low-density lipoproteins; apo-B; atherosclerosis

Document Type: Research article

DOI: http://dx.doi.org/10.1023/B:BEBM.0000046934.76907.9d

Affiliations: 1: Laboratory for Mechanisms of Atherogenesis, Institute of Experimental Cardiology, Russian Research-and-Production Complex for Cardiology, Russian Ministry of Health; Institute of Atherosclerosis, Russian Academy of Natural Sciences, Moscow., Emai

Publication date: 2004-07-01