Effect of Peptide Pro-Gly-Pro on Stress-Induced Behavioral Changes in Rats

Authors: G. N. Kopylova; S. E. Badmaeva; N. G. Levitskaya; G. E. Samonina; B. A. Umarova; A. A. Guseva

Source: Bulletin of Experimental Biology and Medicine, Volume 138, Number 1, July 2004 , pp. 5-7(3)

Publisher: Springer

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Abstract:

Tripeptide PGP in a dose of 1 mg/kg had a correcting effect on behavioral disorders in rats induced by stress exposure (forced swimming). PGP prevented the increase in anxiety and decrease in orientation and exploratory activity. Our results suggest that the effect of this peptide is realized via central nervous structures involved in organism's response to stress factors.

Keywords: stress; behavior; regulatory peptides

Document Type: Research article

DOI: http://dx.doi.org/10.1023/B:BEBM.0000046923.37415.4e

Affiliations: 1: Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University., Email: samonina@pisem.net

Publication date: 2004-07-01