Erythropoietic Activity of Preparations Containing Receptors and Antibodies to Erythropoietin in Ultralow Doses

Authors: Zhdanov V.V.; Simanina E.V.; Dugina Y.L.; Stavrova L.A.; Gur'yantseva L.A.; Epstein O.I.; Dygai A.M.; Goldberg E.D.

Source: Bulletin of Experimental Biology and Medicine, Volume 135, Supplement 1, 2003 , pp. 73-74(2)

Publisher: Springer

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Abstract:

We compared the erythropoiesis-stimulating effects of ultralow doses of erythropoietin receptors and antibodies to erythropoietin in intact mice. Antibodies to erythropoietin, but not erythropoietin receptors, possessed considerable erythropoiesis-activating properties.

Keywords: erythropoietin; antibodies; ultralow doses; erythropoiesis; receptors

Language: English

Document Type: Research article

Affiliations: 1: Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences; “Materia Medica Holding” Research-and-Production Company, Moscow

Publication date: 2003-01-01