Effect of Injection of Testosterone Derivatives to Pregnant Rats on the Brain of Their One-Day Offspring

Author: Ryzhavskii B.Y.¹

Source: Bulletin of Experimental Biology and Medicine, Volume 134, Number 5, November 2002 , pp. 509-511(3)

Publisher: Springer

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Abstract:

Intramuscular injection of Sustanon-250, a drug with testosterone derivatives of various action rate and duration, to rats on day 19 of gestation affected brain development in their offspring. This effect manifested in greater brain weight and neocortex thickness, smaller density of neurons in the developing cortical layer V, and larger size of these neurons and their nuclei and cytoplasm in comparison with control neonatal rats. These data attest to accelerated cerebral development in the offspring of experimental rats in comparison offspring of control rats.

Keywords: brain; development; androgens; pregnancy; morphometry

Language: English

Document Type: Research article

Affiliations: 1: Department of Histology, Far Eastern State Medical University, Khabarovsk

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