Pine Resin and Biopin Ointment: Effects of Water-Soluble Fractions on Cytokine Production by Peripheral Blood Neutrophils

Authors: Simbirtsev A.S.¹; Konusova V.G.¹; Mchedlidze G.S.¹; Paramonov B.A.¹; Chebotarev V.Y.¹

Source: Bulletin of Experimental Biology and Medicine, Volume 134, Number 2, August 2002 , pp. 151-155(5)

Publisher: Springer

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Abstract:

We studied the effects of water-soluble fractions of pine resin and Biopin-10 and Biopin-20 ointments used for the therapy of burns, wounds, and purulent and inflammatory diseases on spontaneous and induced synthesis of tumor necrosis factor and interleukins 1, 2, and 8 by human peripheral blood neutrophils in vitro. These preparations contain various bioactive substances producing opposite and dose-dependent immunomodulatory effects. Our results indicate that the composition and doses of preparations should be selected to achieve the maximum therapeutic effect.

Keywords: pine resin; Biopin ointment; chromatographic fractionation; immunomodulatory effect

Language: English

Document Type: Research article

Affiliations: 1: Institute of High-Purity Biological Preparations; St. Petersburg-Technology, St. Petersburg. elena@tech.spb.ru

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