Effect of beta-Amyloid Peptide Fragment 25-35 on Nonselective Permeability of Mitochondria

Authors: Shevtzova E.F.; Kireeva E.G.; Bachurin S.O.

Source: Bulletin of Experimental Biology and Medicine, Volume 132, Number 6, December 2001 , pp. 1173-1176(4)

Publisher: Springer

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Abstract:

Beta-Amyloid peptide fragment 25-35 potentiated phosphate- and calcium-induced opening of mitochondrial channels and caused swelling of mitochondria (even without exogenous calcium and phosphate). These changes were accompanied by accumulation of lipid peroxidation products in mitochondria. Specific inhibitors of mitochondrial channels ADP and cyclosporine A prevented beta-amyloid peptide-induced swelling of mitochondria. Our findings suggest that potentiation of mitochondrial channel opening is an important component of the neurodegenerative effect of beta-amyloid.

Keywords: mitochondria; beta-amyloid; neurodegeneration; cyclosporine-sensitive mitochondrial channels; lipid peroxidation

Language: English

Document Type: Regular paper

Affiliations: 1: Laboratory of Neurochemistry, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka. shevt@ipac.ac.ru

Publication date: 2001-12-01