Corrective Effect of Clotrimazole and -Ionol during Exposure to Thiophenol

Authors: Dadali V.A.¹; Golovanova N.E.¹; Pavlova R.N.¹; Dzhangulova N.E.¹; Vinogradova V.E.¹

Source: Bulletin of Experimental Biology and Medicine, Volume 130, Number 11, November 2000 , pp. 1090-1092(3)

Publisher: Springer

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Abstract:

Toxic effect of thiophenol on rats can be prevented by injection of antioxidant beta -ionol and clotrimazole, an inductor of phase I and II detoxication enzymes. Both agents increase o-demethylase activity of cytochrome P-450, but do not prevent inhibition of its water-soluble form, and activate cytosol and microsomal glutathione-dependent enzymes. Both agents protected erythrocytes from peroxide damage by thiophenol and simultaneously enhanced its prooxidant effect in the liver.

Keywords: correction; intoxication; clotrimazole; beta -ionol; glutathione-dependent enzymes; cytochrome P-450

Language: English

Document Type: Regular paper

Affiliations: 1: I. I. Metchnikov St. Petersburg State Medical Academy

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