Corrective Effect of Clotrimazole and -Ionol during Exposure to Thiophenol

Authors: Dadali V.A.; Golovanova N.E.; Pavlova R.N.; Dzhangulova N.E.; Vinogradova V.E.

Source: Bulletin of Experimental Biology and Medicine, Volume 130, Number 11, November 2000 , pp. 1090-1092(3)

Publisher: Springer

Abstract:

Toxic effect of thiophenol on rats can be prevented by injection of antioxidant -ionol and clotrimazole, an inductor of phase I and II detoxication enzymes. Both agents increase o-demethylase activity of cytochrome P-450, but do not prevent inhibition of its water-soluble form, and activate cytosol and microsomal glutathione-dependent enzymes. Both agents protected erythrocytes from peroxide damage by thiophenol and simultaneously enhanced its prooxidant effect in the liver.

Keywords: correction; intoxication; clotrimazole; -ionol; glutathione-dependent enzymes; cytochrome P-450

Language: English

Document Type: Regular paper

Affiliations: 1: I. I. Metchnikov St. Petersburg State Medical Academy

Publication date: 2000-11-01

• In this: publication
• By this: publisher
• In this Subject: Biology ,  Medicine (General)
• By this author: Dadali V.A. ;  Golovanova N.E. ;  Pavlova R.N. ;  Dzhangulova N.E. ;  Vinogradova V.E.

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