Predicting Pregnancy in HIV-1-Discordant Couples

Authors: Guthrie, Brandon1; Choi, Robert2; Bosire, Rose3; Kiarie, James4; Mackelprang, Romel5; Gatuguta, Anne6; John-Stewart, Grace5; Farquhar, Carey5

Source: AIDS and Behavior, Volume 14, Number 5, October 2010 , pp. 1066-1071(6)

Publisher: Springer

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Abstract:

This study examines the incidence and predictors of pregnancy in HIV-1-discordant couples from Nairobi, Kenya. Women from 454 discordant couples were followed for up to 2 years. One-year cumulative incidence of pregnancy was 9.7%. Pregnancy rates did not differ significantly between HIV-1-infected and uninfected women (HR = 1.46). The majority of pregnancies occurred among women < 30 years old reporting a desire for future children (1-year incidence 22.2%). Pregnancy rates may be high among discordant couples, indicating desire for children may override concerns of HIV-1 transmission and increase unprotected sex, and highlighting the need to make conception safer.

Keywords: Discordant couples; HIV; Predictors; Pregnancy; Risk factor; Serodiscordant

Document Type: Research Article

DOI: http://dx.doi.org/10.1007/s10461-010-9716-x

Affiliations: 1: Department of Epidemiology, University of Washington, Box 359909, 325 Ninth Avenue, Seattle, WA, 98104-2499, USA, Email: brguth@u.washington.edu 2: Department of Medicine, University of Washington, Seattle, WA, USA 3: Centre for Public Health Research, Kenya Medical Research Institute, Nairobi, Kenya 4: Department of Obstetrics and Gynaecology, University of Nairobi, Nairobi, Kenya 5: Department of Epidemiology, University of Washington, Box 359909, 325 Ninth Avenue, Seattle, WA, 98104-2499, USA 6: Department of Community Health, University of Nairobi, Nairobi, Kenya

Publication date: October 1, 2010

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