A Generic View of Classic Microbial Growth Models

Author: van den Berg H.A.

Source: Acta Biotheoretica, Volume 46, Number 2, 1998 , pp. 117-130(14)

Publisher: Springer

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Abstract:

General theoretical aspects are reviewed of models for microbial growth and endogenous metabolism. The focus is on a generic cell model with two components. Growth is represented as the increase of one of these components (the structural scaffolding or 'frame'). A novel feature of the present generic model is the explicit modelling of (partial) metabolic shutdown under conditions where maintenance requirements cannot be met.

Two different approaches to mechanistic underpinnings for the classic models are outlined. The first approach is based on a bimolecular reaction between the non-permanent biomass component and the permanent biomass component. The second approach is based on cellular control systems.

Keywords: growth models; endogenous metabolism; Monod model; Droop quota model

Language: English

Document Type: Regular paper

Affiliations: 1: Department of Theoretical Biology, Vrije Universiteit Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands

Publication date: 1998-06-01