Y chromosomal haplogroup J as a signature of the post-neolithic colonization of Europe
Authors: Giacomo, F.1; Luca, F.2; Popa, L.3; Akar, N.4; Anagnou, N.5; Banyko, J.6; Brdicka, R.7; Barbujani, G.8; Papola, F.9; Ciavarella, G.10; Cucci, F.11; Stasi, L.12; Gavrila, L.3; Kerimova, M.13; Kovatchev, D.14; Kozlov, A.15; Loutradis, A.16; Mandarino, V.2; Mammi′, C.17; Michalodimitrakis, E.5; Paoli, G.18; Pappa, K.5; Pedicini, G.19; Terrenato, L.1; Tofanelli, S.18; Malaspina, P.1; Novelletto, A.20
Source: Human Genetics, Volume 115, Number 5, October 2004 , pp. 357-371(15)
Abstract:In order to attain a finer reconstruction of the peopling of southern and central-eastern Europe from the Levant, we determined the frequencies of eight lineages internal to the Y chromosomal haplogroup J, defined by biallelic markers, in 22 population samples obtained with a fine-grained sampling scheme. Our results partially resolve a major multifurcation of lineages within the haplogroup. Analyses of molecular variance show that the area covered by haplogroup J dispersal is characterized by a significant degree of molecular radiation for unique event polymorphisms within the haplogroup, with a higher incidence of the most derived sub-haplogroups on the northern Mediterranean coast, from Turkey westward; here, J diversity is not simply a subset of that present in the area in which this haplogroup first originated. Dating estimates, based on simple tandem repeat loci (STR) diversity within each lineage, confirmed the presence of a major population structuring at the time of spread of haplogroup J in Europe and a punctuation in the peopling of this continent in the post-Neolithic, compatible with the expansion of the Greek world. We also present here, for the first time, a novel method for comparative dating of lineages, free of assumptions of STR mutation rates.
Document Type: Research Article
Affiliations: 1: Department of Biology, University “Tor Vergata”, Rome, Italy, 2: Department of Cell Biology, University of Calabria, Via P. Bucci, 87030, Rende, Italy, 3: Genetics Department, University of Bucharest, Bucharest, Rumania, 4: Pediatrics Department, Ankara University, Ankara, Turkey, 5: School of Medicine, University of Athens , Athens, Greece, 6: University of P. J. Safarik, Kosice, Slovak Republic, 7: Institute for Haematology and Blood Transfusion, Prague, Czech Republic, 8: Department of Biology, University of Ferrara, Ferrara, Italy, 9: Centro Regionale di Immunoematologia e Tipizzazione Tissutale, L’Aquila, Italy, 10: IRCCS Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Italy, 11: Az. Osp. Perrino, Brindisi, Italy, 12: A.S.L. 1, Paola, Italy, 13: Department of Hygiene, Azerbaijan Medical University, Baku, Azerbaijan, 14: Department of Biology, Medical University, Varna, Bulgaria, 15: Arct-An C Innovative Laboratory, Moscow, Russian Federation, 16: Ministry of Health Center for Thalassemia, Athens, Greece, 17: A.S.L. BMM, Reggio Calabria, Italy, 18: Department of Ethology, Ecology and Evolution, University of Pisa, Pisa, Italy, 19: Az. Osp. Rummo, Benevento, Italy, 20: Department of Cell Biology, University of Calabria, Via P. Bucci, 87030, Rende, Italy, Email: firstname.lastname@example.org
Publication date: 2004-10-01
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- By this: publisher
- In this Subject: Genetics
- By this author: Giacomo, F. ; Luca, F. ; Popa, L. ; Akar, N. ; Anagnou, N. ; Banyko, J. ; Brdicka, R. ; Barbujani, G. ; Papola, F. ; Ciavarella, G. ; Cucci, F. ; Stasi, L. ; Gavrila, L. ; Kerimova, M. ; Kovatchev, D. ; Kozlov, A. ; Loutradis, A. ; Mandarino, V. ; Mammi′, C. ; Michalodimitrakis, E. ; Paoli, G. ; Pappa, K. ; Pedicini, G. ; Terrenato, L. ; Tofanelli, S. ; Malaspina, P. ; Novelletto, A.