Resting plasma and salivary IL-6 concentrations are not correlated in distance runners

Authors: Cox, Amanda1; Pyne, David2; Gleson, Maree3; Callister, Robin3

Source: European Journal of Applied Physiology, Volume 103, Number 4, July 2008 , pp. 477-479(3)

Publisher: Springer

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content

Abstract:

Measurement of IL-6 has been widely undertaken to examine inflammatory and immune responses to exercise. Use of salivary IL-6 offers an alternative to the invasive collection procedures required for IL-6 measurement in plasma samples. Rarely, however, has the degree of association between plasma and salivary IL-6 been reported. The aim of the current study was to investigate the relationship between resting salivary and plasma IL-6 concentrations in 45 trained distance runners (36 males, 9 females; age: 35.1 ± 8.0 y, mean ± SD). Plasma and saliva samples were collected from athletes under resting conditions. Plasma IL-6 concentrations were determined using a Bioplex suspension array system and commercially available reagents. Salivary IL-6 concentrations were determined using a commercially available high-sensitivity ELISA kit. At rest, the mean (± SD) plasma IL-6 concentration was 3.43 ± 3.75 pg mL−1 compared to a mean salivary IL-6 concentration of 1.80 ± 4.25 pg mL−1. IL-6 concentrations in plasma and saliva samples were not correlated (r = −0.031, p = 0.85). At rest, salivary IL-6 concentrations do not reflect plasma IL-6 concentrations. The potential for salivary IL-6 to act as a surrogate marker for plasma IL-6 responses when examining inflammatory and immune responses to exercise, therefore, appears unlikely.

Keywords: Cytokines; Immunity; Athletes; Exercise

Document Type: Research article

DOI: 10.1007/s00421-008-0722-x

Affiliations: 1: Department of Physiology, Australian Institute of Sport, PO Box 176, Canberra, Belconnen, ACT, 2616, Australia, Email: amanda.cox@ausport.gov.au 2: Department of Physiology, Australian Institute of Sport, PO Box 176, Canberra, Belconnen, ACT, 2616, Australia 3: School of Biomedical Sciences, Faculty of Health, University of Newcastle, Callaghan, NSW, 2308, Australia

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$47.00 plus tax      Refund Policy

 

OR

Back to top

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages.
Page Help Click here for Page Help
Shopping cart
Tools
Sign in






Need to register?
Sign up here
Text size: A | A | A | A