Authors: Bilgin, Tufan¹; Ozan, Hakan²; Özuysal, Sema³; Özkan, Lütfi⁴

Source: Archives of Gynecology and Obstetrics, Volume 269, Number 2, January 2004 , pp. 159-160(2)

Publisher: Springer

Abstract:

A 26-year-old woman who had been treated for nonmetastatic gestational trophoblastic tumor with three courses of methotrexate with folinic acid rescue and had been lost to follow up for 4 years was referred with the fractional curettage diagnosis of choriocarcinoma that had been performed for abnormal vaginal bleeding. Her serum beta human chorionic gonadotropin (βhCG) was 706,000 mIU/mL and there were multiple pulmonary metastatic foci. The uterus was 12 weeks pregnant-size and a 6×6-cm tumor mass was seen within the anterior uterine wall at ultrasonography. Following total abdominal hysterectomy etoposide, methotrexate, actinomycin-D, vincristine and cyclophosphamide (EMA/CO) regimen was given. Whole brain radiation of 30 Gy in 3 weeks for brain metastasis, discovered in magnetic resonance imaging was given after the first course. Since serum βhCG levels plateaued after three courses of chemotherapy and multiple pulmonary metastases persisted, treatment was shifted to etoposide, methotrexate, actinomycin-D, etoposide, cisplatin (EMA/EP) regimen. She was in remission after three courses of chemotherapy.

Keywords: Choriocarcinoma; Hysterectomy; Chemotherapy

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s00404-002-0422-4

Affiliations: 1: Department of Obstetrics and Gynecology, Faculty of Medicine, Uludag University, Bursa, Turkey, Email: tbilgin@uludag.edu.tr 2: Department of Obstetrics and Gynecology, Faculty of Medicine, Uludag University, Bursa, Turkey, 3: Department of Pathology, Faculty of Medicine, Uludag University, Bursa, Turkey, 4: Department of Radiation Oncology, Faculty of Medicine, Uludag University, Bursa, Turkey,

Publication date: 2004-01-01

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