Bone morphogenetic protein 2 accelerates osteointegration and remodelling of solvent-dehydrated bone substitutes
Source: Archives of Orthopaedic and Trauma Surgery, Volume 124, Number 6, July 2004 , pp. 410-414(5)
Abstract:lt was the purpose of this study to investigate how bone morphogenetic protein 2 (BMP-2) influences remodelling and the biomechanics of solvent-dehydrated bone in the long run. Furthermore, the early influence of this growth factor on the substitute was investigated.
Using a weight-bearing animal model, solvent-dehydrated bone was implanted in the tibial head of merino sheep (n=12) after being loaded with BMP-2 (100 g/100 l). At 4 weeks (n=6) and 9 months (n=6) after surgery, histomorphological, histomorphometrical and biomechanical investigations were performed.
At 9 months after implantation of BMP-2-loaded specimens, the bone per tissue volume was high, with levels above those of physiological cancellous bone. The amount of remaining solvent-dehydrated bone was markedly decreased, and in contrast, the amount of newly formed bone was extremely high. The specimen degradation had already occurred within the first 4 weeks after implantation, showing no further impact throughout the 9-month period. Biomechanical investigations at 9 months after implantation demonstrated a yield strength which achieved levels at least equivalent to physiological cancellous bone. BMP-2 showed no significant impact on the biomechanical properties after 4 weeks, compared to specimens prior to implantation.
BMP-2 predominantly has an impact on the early implant degradation as well as bone formation, which leads to an almost completed bone remodelling of the solvent-dehydrated specimen within the study period of 9 months.
Document Type: Research Article
Affiliations: 1: Orthopedic Department, Städt. Krankenhaus Sindelfingen, Arthrur-Gruber-Str. 70, 71065, Sindelfingen, Germany, Email: firstname.lastname@example.org 2: Orthopaedic Department, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany, 3: German Red Cross Blood Transfusion Service Ulm, Helmholzstrasse 10, 89081, Ulm, Germany, 4: Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholzstrasse 14, 89081, Ulm, Germany, 5: Orthopaedic Department, CarI Gustav Carus University Dresden, Fetscherstrasse 74, 01307, Dresden, Germany,
Publication date: July 2004