Authors: Nakamura, Hideki¹; Tateishi, Seiko²; Kawakami, Atsushi²; Ida, Hiroaki²; Fukuda, Taku²; Sasaki, Michiyo³; Koide, Yuji³; Ashizawa, Naoto³; Seto, Shinji³; Hayashi, Tomayoshi⁴; Sato, Shinichi⁵; Eguchi, Katsumi²

Source: Rheumatology International, Volume 28, Number 12, October 2008 , pp. 1273-1275(3)

Publisher: Springer

Abstract:

A 54-year-old female was diagnosed as mixed connective tissue disease (MCTD) complicated with secondary Sjögren's syndrome. Although she had no dyspnea on exertion, the chest X-ray showed cardiomegaly with interstitial pneumonia. The echocardiogram demonstrated asymmetric hypertrophy of the interventricular septum. Diagnosis of hypertrophic obstructive cardiomyopathy (HOCM) was confirmed by left ventriculography and myocardial biopsy. She was treated with prednisolone, resulting in improvement of swollen hand, elevated muscle enzymes and interstitial pneumonia. A rare complication of HOCM with MCTD was described.

Keywords: Mixed connective tissue disease; Hypertrophic obstructive cardiomyopathy; HLA-DR4

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s00296-008-0608-6

Affiliations: 1: First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki City, Nagasaki, 852-8501, Japan, Email: nakamura_hideki911@yahoo.co.jp 2: First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki City, Nagasaki, 852-8501, Japan 3: Department of Cardiovascular Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan 4: Department of Pathology, Nagasaki University Hospital, Nagasaki, Japan 5: Department of Dermatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan

Publication date: 2008-10-01

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• By this author: Nakamura, Hideki ;  Tateishi, Seiko ;  Kawakami, Atsushi ;  Ida, Hiroaki ;  Fukuda, Taku ;  Sasaki, Michiyo ;  Koide, Yuji ;  Ashizawa, Naoto ;  Seto, Shinji ;  Hayashi, Tomayoshi ;  Sato, Shinichi ;  Eguchi, Katsumi

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