IngentaConnect Ondansetron for the Prevention of Postoperative Nausea and Vomiti...

Authors: Barbosa, Marcus¹; Nahas, Fabio²; Ferreira, Lydia²; Farah, Andréia²; Bariani, Roberta²; João, Benedito³

Source: Aesthetic Plastic Surgery, Volume 28, Number 1, January 2004 , pp. 33-36(4)

Publisher: Springer

Abstract:

Ondansetron has been used widely in plastic surgery to prevent postoperative nausea and vomiting. A literature search showed controversial dosages of this drug, and because of its short half-life, its use only before anesthetic induction could have a limited effect. The purpose of this study was to assess the efficacy of intravenous (IV) ondansetron (4 mg) for aesthetic plastic surgery performed with the patient under general anesthesia and the prophylaxis of postoperative nausea and vomiting (PONV) in two situations: (a) only before anesthetic induction and (b) before anesthetic induction and immediately before extubation.

Of the 60 patients who had general anesthesia for aesthetic plastic surgery, 30 received 4 mg of IV ondansetron before anesthetic induction (control group) and 30 received 4 mg of IV ondansetron before anesthetic induction plus 4 mg IV immediately before extubation (experimental group). The PONV was recorded in the postanesthetic care unit and in the hospital room.

The total occurrence of PONV (n = 60) was 6.7%. In the postanesthetic care unit, one patient in the experimental group (3.3%) manifested this symptom. In the hospital room, two patients in the control group (6.7%) and one patient in the experimental group (3.3%) manifested PONV.

According to the findings, there was no statistical difference between the groups. However, the dosage used in the control group was effective and less expensive.

Keywords: Nausea; Ondansetron; Plastic surgery; Postoperative; Vomiting

Document Type: Research article

DOI: 10.1007/s00266-004-3087-5

Affiliations: 1: Federal University of São Paulo (EPM) and Plastic Surgery Residency Program, Hospital Jaraguá, São Paulo, SP / Brazil, Email: drmbarbosa@ig.com.br 2: Federal University of São Paulo (EPM) and Plastic Surgery Residency Program, Hospital Jaraguá, São Paulo, SP / Brazil, 3: Alameda Santos, 687, Ap. 133, 01419-001 São Paulo, SP / Brazil,

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Ondansetron for the Prevention of Postoperative Nausea and Vomiting: Which is the Best Dosage for Aesthetic Plastic Surgery?