Differentiated adamantinoma of the fibula: a rhabdoid variant

Authors: Povýšil, C.¹; Kohout, A.²; Urban, K.³; Horák, M.⁴

Source: Skeletal Radiology, Volume 33, Number 8, August 2004 , pp. 488-492(5)

Publisher: Springer

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Abstract:

A benign- appearing osteolytic lesion surrounded by a sclerotic rim was found in the upper fibula of a 25-year-old man. Based on histological features the definitive diagnosis of osteofibrous dysplasia–differentiated adamantinoma was made. The correct histological diagnosis of differentiated adamantinoma depends on factors such as the uniform predominance of an osteofibrous dysplasia-like pattern, and scattered epithelial elements positive for cytokeratin and vimentin. In this case the scattered epithelial cells had abundant eosinophilic cytoplasm and resembled rhabdoid elements, but immunohistochemistry proved their epithelial origin.

Keywords: Fibula; Osteofibrous dysplasia; Differentiated adamantinoma; Radiographs

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s00256-004-0755-0

Affiliations: 1: Institute of Pathology, 1st Medical Faculty, Charles University, Institute for Postgraduate Medical Studies, Studničkova 2, 128 00, Prague 2, Czech Republic, Email: ctibor.povysil@lf1.cuni.cz 2: The Fingerland Department of Pathology, Medical Faculty Hradec Králové, Charles University, 500 05, Hradec Králové, Czech Republic, 3: Department of Orthopedic Surgery, Medical Faculty Hradec Králové, Charles University, 500 05, Hradec Králové, Czech Republic, 4: Department of Radiodiagnostics, 1st Medical Faculty and Teaching Hospital Na Bulovce, Charles University, Budínova 2, 180 00, Prague 8, Czech Republic,

Publication date: 2004-08-01