Authors: Sutherland, Wayne¹; Jong, Sylvia²; Walker, Robert²

Source: Lipids, Volume 42, Number 10, October 2007 , pp. 901-911(11)

Publisher: Springer

Abstract:

Postprandial chylomicrons are potent ultimate acceptors of cell membrane cholesterol and are believed to accelerate reverse cholesterol transport (RCT). We compared the effects of meals rich in polyunsaturated fat (PUFA) and either high (605 mg) or low (151 mg) in cholesterol and a meal rich in dairy fat (DF) in the form of cream on net in vitro transport of red blood cell (RBC) membrane cholesterol to 4 and 6 h postprandial plasma in eight normotriglyceridemic (NTG-H) and eight hypertriglyceridemic (HTG-H) men with mild to moderate hypercholesterolemia. In HTG-H men, cell cholesterol accumulation in 6-h postprandial plasma was significantly (P = 0.02) less after the PUFA-HC meal compared with the other meals. The significant (P < 0.001) increase in cell plus endogenous cholesterol accumulation in the triglyceride-rich lipoprotein (TRL) fraction of 4 h postprandial plasma incubated with RBC was significantly (P = 0.007) higher after the PUFA-HC meal compared with DF meal in HTG-H men. In NTG-H men, cholesterol accumulation in plasma and plasma lipoproteins in the presence and absence of RBC was not significantly affected by the type of meal ingested. These data suggest that addition of large amounts of cholesterol to a PUFA meal may impair diffusion-mediated transport of cell membrane cholesterol to postprandial plasma and that replacing DF with PUFA in a meal increases postprandial lipemia and may potentially increase cholesterol accumulation in atherogenic postprandial TRL in HTG-H men.

Keywords: Postprandial lipemia; Reverse cholesterol transport; Dietary cholesterol; Polyunsaturated fat; Dairy fat; Hyperlipidemia

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s11745-007-3101-1

Affiliations: 1: Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, P.O. Box 913, Dunedin, 9054, New Zealand, Email: wayne.sutherland@stonebow.otago.ac.nz 2: Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, P.O. Box 913, Dunedin, 9054, New Zealand

Publication date: 2007-10-01

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