IngentaConnect Intrahepatic Cholangiocarcinoma and Combined Hepatocellular-Chola...

Authors: Portolani, Nazario¹; Baiocchi, Gian²; Coniglio, Arianna¹; Piardi, Tullio¹; Grazioli, Luigi³; Benetti, Anna⁴; Ferrari Bravo, Andrea¹; Giulini, Stefano¹

Source: Annals of Surgical Oncology, Volume 15, Number 7, July 2008 , pp. 1880-1890(11)

Publisher: Springer

Abstract:

Intrahepatic cholangiocarcinoma (ICC) is an unusual tumour.

The clinicopathological data of 67 patients with ICC and combined hepatocellular-cholangiocarcinoma (HCC-ICC) are presented.

HCV-HBV infection was present in 37.3% and chronic liver disease in 38.7% of cases, a rate higher than in the normal population; in these patients the cancer was small, often asymptomatic and of combined type. Liver resection was performed in 51 patients; at 1, 3 and 5 years, overall survival was 87.9%, 59.0%, and disease-free survival was 47.7% and 78.8%, 51.4%, and 46.7%, respectively. The better results were in the group of cirrhotic patients in whom ICC was diagnosed by a screening program for HCC (5-year survival 76.6%). Nodal metastasis showed negative prognostic value for both overall and disease-free survival; in N+ patients mean survival was 14.7 months after liver resection and lymph node dissection.

Viral infection and cirrhosis may be considered risk conditions for ICC and combined HCC-ICC; in resected patients survival was good. Nodal metastases must not be considered a contraindication for liver resection.

Keywords: HCC; Cholangiocarcinoma; Liver surgery; Hepatitis infection; Cirrhosis

Document Type: Research article

DOI: 10.1245/s10434-008-9933-y

Affiliations: 1: Department of Medical and Surgical Sciences, Surgical Clinic, Brescia University, P.le Spedali Civili, 1, 25123, Brescia, Italy 2: Department of Medical and Surgical Sciences, Surgical Clinic, Brescia University, P.le Spedali Civili, 1, 25123, Brescia, Italy, Email: baioksurg@hotmail.com 3: Department of Radiology, Azienda Ospedaliera Spedali Civili di Brescia, Brescia, Italy 4: Department of Pathology, Brescia University, Brescia, Italy

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Intrahepatic Cholangiocarcinoma and Combined Hepatocellular-Cholangiocarcinoma: A Western Experience