IngentaConnect Multivariate Analysis of the Pathologic Features of Esophageal Sq...

Authors: Koike, Masahiko¹; Kodera, Yasuhiro²; Itoh, Yuichi²; Nakayama, Goro²; Fujiwara, Michitaka²; Hamajima, Nobuyuki³; Nakao, Akimasa²

Source: Annals of Surgical Oncology, Volume 15, Number 7, July 2008 , pp. 1977-1982(6)

Publisher: Springer

Abstract:

Tumor budding has been suggested to be a prognostic factor in various cancers but has never been studied in esophageal cancer.

In this study, the microscopic finding of tumor budding in esophageal squamous cell carcinoma was correlated with outcome after esophagectomy. One hundred and thirty-six patients undergoing a curative esophagectomy were assigned to either a frequent (n = 82) or rare (n = 54) group according to the microscopically observed frequency of tumor budding in the tumor.

The 5-year survival rates after esophagectomy were 35.4% for the frequent group and 81.3% for the rare group. Multivariate analysis using the Cox proportional hazards model by a stepwise method identified this morphological variable as a significant independent prognostic factor.

Tumor budding in esophageal squamous cell carcinoma reflects the biological activity of the tumor and may be a useful prognostic indicator.

Keywords: Tumor budding; Prognosis; Esophageal cancer; Squamous cell cancer; Esophagectomy

Document Type: Research article

DOI: 10.1245/s10434-008-9901-6

Affiliations: 1: Department of Surgery II, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan, Email: dockoike@med.nagoya-u.ac.jp 2: Department of Surgery II, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan 3: Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

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Multivariate Analysis of the Pathologic Features of Esophageal Squamous Cell Cancer: Tumor Budding Is a Significant Independent Prognostic Factor