Authors: Caudle, A.¹; Kim, H.¹; Tepper, J.²; O'Neil, B.³; Lange, L.⁴; Goldberg, R.³; Bernard, S.³; Calvo, B.¹; Meyers, M.⁵

Source: Annals of Surgical Oncology, Volume 15, Number 7, July 2008 , pp. 1931-1936(6)

Publisher: Springer

Abstract:

Although diabetic patients with rectal cancer have poorer outcomes than their nondiabetic counterparts, few studies have looked at diabetics' response to therapy as an explanation for this disparity. This study compares the neoadjuvant chemoradiotherapy (CRT) response in diabetic and nondiabetic patients with locally advanced rectal cancers.

This is a single-institution, retrospective review of rectal cancer patients who received CRT followed by resection from 1995 to 2006. Pretreatment tumor-node-metastasis (TNM) staging was determined using endorectal ultrasound, computed tomography (CT) scan, and magnetic resonance imaging (MRI); post-treatment staging was determined by pathological review.

110 patients were included; seventeen had diabetes and 93 were nondiabetics. Pretreatment staging was similar in both groups. Sixteen of the diabetics (94%) completed CRT compared to 92% (86/93) of the nondiabetics. Tumor downstaging rates were similar in the two groups (53% in diabetics, 52% in nondiabetics). Nondiabetic patients had a higher rate of nodal downstaging although not statistically significant (67% versus 27%, P = 0.80). While none of the diabetics patients achieved a pathologic complete response (pCR), 23% (21/93) of the nondiabetics did (P = 0.039). Local progression rates were higher in the diabetic group (24% versus 5%, P = 0.046).

Our study shows that neoadjuvant chemoradiotherapy in rectal cancer is less effective in diabetic patients than in nondiabetics. While minimal differences are found in the rate of downstaging, the rate of achieving a complete pathologic response was significantly higher in nondiabetic patients, and in fact was not seen in any of our diabetic patients. This may explain the poorer outcomes seen in diabetic patients with rectal cancer.

Keywords: Rectal cancer; Chemotherapy; Radiation therapy; Diabetes

Document Type: Research article

DOI: http://dx.doi.org/10.1245/s10434-008-9873-6

Affiliations: 1: Division of Surgical Oncology, University of North Carolina, Chapel Hill, NC, USA 2: Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC, USA 3: Department of Medical Oncology, UNC School of Medicine, UNC School of Medicine, Chapel Hill, NC, USA 4: Department of Genetics, University of North Carolina, Chapel Hill, NC, USA 5: Division of Surgical Oncology, University of North Carolina, Chapel Hill, NC, USA, Email: Michael_Meyers@med.unc.edu

Publication date: 2008-07-01

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