IngentaConnect Expression of Human Leukocyte Antigen G (HLA-G) Correlates with P...

Authors: Yie, Shang-mian¹; Yang, Hong²; Ye, Shang-rong³; Li, Ke²; Dong, Dan-dan²; Lin, Xin-mei³

Source: Annals of Surgical Oncology, Volume 14, Number 10, October 2007 , pp. 2721-2729(9)

Publisher: Springer

Abstract:

We had previously demonstrated that human leukocyte antigen G (HLA-G) was expressed in a majority of primary colorectal carcinomas and that the detection of HLA-G expression had a strong and independent prognostic value for that cancer. Currently, we investigate whether or not HLA-G is also expressed in patients with gastric carcinoma and whether the expression has any clinical application value.

The expression of HLA-G was investigated immunohistochemically in 160 patients with gastric carcinoma. The correlation between HLA-G status and various clinicopathological parameters was analyzed with the levels of HLA-G expression used to compare the survival length amongst patients.

HLA-G protein expression was observed in 71% (113 of 160) of the primary site of gastric carcinomas, but not in the normal stomach tissues. HLA-G expression in the tumors was significantly correlated with the tumor location, histological grade, depth of invasion, lymph nodal metastasis, clinical stages of the disease, and host immune response (P = .012, .008, .001, .038, .030, and .016, respectively). Patients with HLA-G positive tumors had a significantly shorter survival time than those patients with tumors that were HLA-G negative (P = .001). As well, in multivariate analysis, HLA-G demonstrated an independent prognostic factor (P = .0001, relative risk 9.08; 95% confidence interval, 3.44-24.0).

Overall, our results indicated that the expression of HLA-G is a characteristic feature of gastric carcinoma and that immunostaining by anti-HLA-G antibody may be a potentially useful prognostic indicator.

Keywords: Human leukocyte antigen G (HLA-G); Immunohistochemistry; Gastric carcinoma; Prognosis

Document Type: Research article

DOI: 10.1245/s10434-007-9464-y

Affiliations: 1: Chengdu Bioengineering Institute for Cancer Research, Chengdu, Sichuan, P.R. China, Email: shangmian.yie@gmail.com 2: Department of Pathology, Sichuan Provincial People's Hospital, Chengdu, Sichuan, P.R. China 3: Chengdu Bioengineering Institute for Cancer Research, Chengdu, Sichuan, P.R. China

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Expression of Human Leukocyte Antigen G (HLA-G) Correlates with Poor Prognosis in Gastric Carcinoma