IngentaConnect Biliary Obstruction in Gall Bladder Cancer Is Not Sine Qua Non of...

Authors: Agarwal, Anil¹; Mandal, Sanjoy²; Singh, Shivendra²; Bhojwani, Rajesh²; Sakhuja, Puja³; Uppal, Rajeev⁴

Source: Annals of Surgical Oncology, Volume 14, Number 10, October 2007 , pp. 2831-2837(7)

Publisher: Springer

Abstract:

The presence of biliary obstruction in patients with gallbladder cancer (GBC) is generally viewed as an indicator of advanced disease, inoperability and poor prognosis.

Data was collected from patients with GBC with obstructive jaundice who underwent resection during the period January 2001 to October 2003. Systematic analysis of prospective data was undertaken; patients were analyzed for resectability, post-operative morbidity, mortality and disease-free survival.

During this period 14 patients with GBC with biliary obstruction underwent resection with curative intent. In these jaundiced patients, the resectability rate was 27.45% (14 of 51). In the jaundiced group the mortality was 7.14% the morbidity rate 50%, the mean disease free survival was 23.46 months (median 26 months and range of 2 to 62 months). Seven patients (50%) survived more than two years.

Biliary obstruction in gall bladder cancer is not sine qua non of inoperability and resection results in meaningful prolongation of survival.

Keywords: Gall bladder cancer; Obstructive jaundice; Advanced gall bladder cancer; Gall bladder carcinoma

Document Type: Research article

DOI: 10.1245/s10434-007-9456-y

Affiliations: 1: Department of Gastrointestinal Surgery, GB Pant Hospital & Maulana Azad Medical College, JLN Marg, New Delhi, 110002, India, Email: aka.gis@gmail.com 2: Department of Gastrointestinal Surgery, GB Pant Hospital & Maulana Azad Medical College, JLN Marg, New Delhi, 110002, India 3: Department of Pathology, GB Pant Hospital & Maulana Azad Medical College, JLN Marg, New Delhi, 110002, India 4: Department of Anaesthesiology, GB Pant Hospital & Maulana Azad Medical College, JLN Marg, New Delhi, 110002, India

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Biliary Obstruction in Gall Bladder Cancer Is Not Sine Qua Non of Inoperability