Prognostic Implications of Netrin-1 Expression and Its Receptors in Patients with Adenocarcinoma of the Pancreas

Authors: Link, Björn-Christian; Reichelt, Uta; Schreiber, Matthias; Kaifi, Jussuf; Wachowiak, Robin; Bogoevski, Dean; Bubenheim, Michael; Cataldegirmen, Guel; Gawad, Karim; Issa, Rana; Koops, Susann; Izbicki, Jakob; Yekebas, Emre

Source: Annals of Surgical Oncology, Volume 14, Number 9, September 2007 , pp. 2591-2599(9)

Publisher: Springer

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Abstract:

To assess the interaction between the expression of netrin-1 or of its receptors to the prognosis of ductal adenocarcinoma of the pancreas.

In 82 patients with resectable pancreatic adenocarcinoma who underwent curative operation, the expression patterns of netrin-1, deleted in colorectal carcinomas (DCC), UNC5H3, and neogenin were determined by immunohistochemical staining. Kaplan-Meier analysis was performed to assess the prognostic relevance of the examined expression patterns.

Median follow-up was 15 ± 19.9 months (range, 4-108 months). Patients suffering from tumors with no or little expression of netrin-1 (n = 67) had a median recurrence-free survival of 10 months (95% CI, 7-13 months), while a middle to strong expression (n = 15) was associated with a significantly worse median recurrence-free survival of only four months (95% CI, three to five months, p = 0.0165). Overall and recurrence-free survival showed no significant differences between the different expression patterns of DCC, UNC5H3 or neogenin. Netrin-1 expression had significant impact (p = 0.001) on overall survival of patients suffering from poorly differentiated tumors. Stratification according to the nodal status revealed significant influence (p = 0.007) of UNC5H3 expression on the overall survival of patients with pN1 status.

Expression of netrin-1 has significant impact on time to tumor relapse in adenocarcinoma of the pancreas. Netrin-1 expression is associated with worse outcome in poorly differentiated pancreatic adenocarcinomas. Risk-stratification according to the UNC5H3 receptor expression pattern shows that node positive patients (pN1) with no to little UNC5H3 expression carry a significantly worse prognosis than those with middle to strong UNC5H3 expression.

Keywords: Pancreatic cancer; Immunohistochemistry; Netrin-1; UNC5H; DCC; Neogenin

Document Type: Research article

DOI: http://dx.doi.org/10.1245/s10434-007-9469-6

Affiliations: 1: Email: blink@uke.uni-hamburg.de

Publication date: 2007-09-01

Prognostic Implications of Netrin-1 Expression and Its Receptors in Patients with Adenocarcinoma of the Pancreas

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