Authors: Kosaka, Yoshimasa; Inoue, Hiroshi; Ohmachi, Takahiro; Yokoe, Takeshi; Matsumoto, Toshifumi; Mimori, Koshi; Tanaka, Fumiaki; Watanabe, Masahiko; Mori, Masaki

Source: Annals of Surgical Oncology, Volume 14, Number 9, September 2007 , pp. 2543-2549(7)

Publisher: Springer

Abstract:

Tripartite motif-containing 29 (TRIM29) belongs to the TRIM protein family, which has unique structural characteristics, including multiple zinc finger motifs and a leucine zipper motif. TRIM29, also known as ataxia telangiectasia group D complementing gene, possesses radiosensitivity suppressor functions. Although TRIM29 has been reported to be underexpressed in prostate and breast cancer, its expression in gastrointestinal cancer has not been studied.

By use of real-time reverse transcriptase-polymerase chain reaction, we analyzed TRIM29 mRNA expression status with respect to various clinicopathological parameters in 124 patients with gastric cancer. An immunohistochemical study was also conducted.

The expression of TRIM29 was far higher in gastric cancer tumor tissue. Increased TRIM29 mRNA expression was markedly associated with such parameters as histological grade, large tumor size, extent of tumor invasion, and lymph node metastasis. In the TRIM29 high-expression group, it was an independent predictor for lymph node metastasis. Furthermore, patients with high TRIM29 mRNA expression showed a far poorer survival rate than those with low TRIM29 mRNA expression.

TRIM29 expression may serve as a good marker of lymph node metastasis in gastric cancer.

Keywords: ATDC; Gastric cancer; Lymph node metastasis; Prognosis; TRIM29

Document Type: Research article

DOI: http://dx.doi.org/10.1245/s10434-007-9461-1

Affiliations: 1: Email: mmori@beppu.kyushu-u.ac.jp

Publication date: 2007-09-01

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