Authors: Cheong, Jae-Ho; Shen, Jia; Song, Chang; Hyung, Woo; Shen, Jian; Choi, Seung; Noh, Sung

Source: Annals of Surgical Oncology, Volume 14, Number 1, January 2007 , pp. 61-68(8)

Publisher: Springer

Abstract:

The survival of patients with stage IV gastric cancer is poor due to frequent peritoneal failure. The aim of this study was to investigate the impact of early postoperative intraperitoneal chemotherapy (EPIC) after cytoreductive surgery on the long-term survival of these patients, as determined by residual disease status.

A total of 154 patients with stage IV gastric cancer were enrolled in our study. All patients underwent potentially curative or palliative resections. After surgery, the residual disease states of the patients were recorded. All patients received EPIC.

Of all 154 patients, R0 resection was achieved in 37, R1 in 56, and R2 in 61. All patients received a mean of 4.3 EPIC perfusions. After a mean followup period of 29 months, 14 patients remained alive. The median survival of all 154 patients was 11.4 months. Survival times were analyzed according to the type of residual tumor; the median survival time was 25.5 months in the R0 group, 15.6 months in the R1 group, and 7.2 months in the R2 group (p < .001). Upon multivariate analysis, the residual tumor states and the cycle of EPIC perfusion were found to be independent prognostic predictors (p < .001 and p = .018, respectively).

The residual tumor status is the most important predictor for the survival of very advanced gastric cancer patients who received cytoreductive surgery and EPIC. Therefore, complete cytoreductive surgery yielding R0 resection is mandatory for achieving the beneficial effects of EPIC.

Keywords: Gastric cancer; EPIC; Cytoreductive surgery; R0 resection

Document Type: Research article

DOI: http://dx.doi.org/10.1245/s10434-006-9205-7

Affiliations: 1: Email: sunghoonn@yumc.yonsei.ac.kr

Publication date: 2007-01-01

Related content

• In this: publication
• By this: publisher
• In this Subject: Oncology
• By this author: Cheong, Jae-Ho ;  Shen, Jia ;  Song, Chang ;  Hyung, Woo ;  Shen, Jian ;  Choi, Seung ;  Noh, Sung

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers