A new photoproduct of the drug furosemide in aqueous media

Authors: Greca, Marina¹; Iesce, Maria¹; Previtera, Lucio²; Rubino, Maria¹; Temussi, Fabio¹

Source: Environmental Chemistry Letters, Volume 2, Number 3, December 2004 , pp. 155-158(4)

Publisher: Springer

Abstract:

The solar phototransformation of furosemide has been investigated in aqueous media. Irradiation of the drug in distilled water, in water and humic acids or nitrate ions, and in sewage sludge water affords a new dehalogenated dimer. The formation of the dimer has been explained by the formation of a cation radical intermediate. The low-measured environmental concentration of furosemide with respect to predicted environmental concentration in the Po and Lambro Rivers could be justified by its phototransformation.

Keywords: Furosemide; Drug; Solar phototransformation; Solar-simulated irradiation

Document Type: Research article

DOI: 10.1007/s10311-004-0080-9

Affiliations: 1: Dipartimento di Chimica Organica e Biochimica, Università Federico II, Via Cynthia 4, 80126, Naples, Italy, 2: Dipartimento di Chimica Organica e Biochimica, Università Federico II, Via Cynthia 4, 80126, Naples, Italy, Email: previter@unina.it

Links for this article

http://www.ingentaconnect.com/klu/10311/2004/00000002/00000003/art00010
http://openurl.ingenta.com/content?genre=article&issn=1610-3653&volume=2&issue=3&spage=155&epage=158
http://dx.doi.org/10.1007/s10311-004-0080-9