IngentaConnect Report of cluster headache in a pair of monozygous twins

Authors: Kowacs, Pedro¹; Piovesan, Elcio²; Werneck, Lineu²; Fameli, Hudson²; Lange, Marcos²; Raskin, Salmo³

Source: The Journal of Headache and Pain, Volume 5, Number 2, August 2004 , pp. 140-143(4)

Publisher: Springer

Abstract:

A pair of identical twins with cluster headache is described. Monozygosity was confirmed by the identification of 14 DNA markers. In spite of harboring the same genes, the clinical picture presented by the twins was not exactly the same. Cluster headache is probably the best known trigeminal-autonomic cephalalgia, but several questions regarding its pathophysiology remain to be answered. The cases described herein reinforce the role of genetic aspects in its etiology.

Keywords: Cluster headache; Genetic aspects; Monozygous twins; Trigeminal-autonomic cephalalgias; Twins

Document Type: Research article

DOI: 10.1007/s10194-004-0082-9

Affiliations: 1: Headache Section, Neurology Division, Internal Medicine Department, Hospital de Clínicas da Universidade Federal do Paraná, Rua General Carneiro 181, Sala 1236, 80060-900, Curitiba, Brazil, Email: cefaleia@hc.ufpr.br 2: Headache Section, Neurology Division, Internal Medicine Department, Hospital de Clínicas da Universidade Federal do Paraná, Rua General Carneiro 181, Sala 1236, 80060-900, Curitiba, Brazil, 3: Laboratório Genétika, Curitiba, Brazil,

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