Authors: Ando, Masahiko¹; Takewa, Yoshiaki²; Nishimura, Takashi³; Yamazaki, Kenji⁴; Kyo, Shunei³; Ono, Minoru⁵; Tsukiya, Tomonori²; Mizuno, Toshihide²; Taenaka, Yoshiyuki²; Tatsumi, Eisuke²

Source: Journal of Artificial Organs, Volume 14, Number 3, September 2011 , pp. 185-191(7)

Publisher: Springer

Abstract:

The effect of rotary left ventricular assist devices (LVADs) on myocardial perfusion has yet to be clearly elucidated, and several studies have shown decreased coronary flow under rotary LVAD support. We have developed a novel pump controller that can change its rotational speed (RS) in synchronization with the native cardiac cycle. The aim of our study was to evaluate the effect of counterpulse mode, which increases the RS in diastole, during coronary perfusion. Experiments were performed on ten adult goats. The EVAHEART LVAD was installed by the left ventricular uptake and the descending aortic return. Ascending aortic flow, pump flow, and coronary flow of the left main trunk were monitored. Coronary flow was compared under four conditions: circuit-clamp, continuous mode (constant pump speed), counterpulse mode (increased pump speed in diastole), and copulse mode (increased pump speed in systole). There were no significant baseline changes between these groups. In counterpulse mode, coronary flow increased significantly compared with that in continuous mode. The waveform analysis clearly revealed that counterpulse mode mainly resulted in increased diastolic coronary flow. In conclusion, counterpulse mode of rotary LVADs can enhance myocardial perfusion. This novel drive mode can provide great benefits to the patients with end-stage heart failure, especially those with ischemic etiology.

Keywords: Left ventricular assist device; Myocardial perfusion; Counterpulsation

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s10047-011-0573-9

Affiliations: 1: Department of Artificial Organ, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan, Email: masandoo@hotmail.com 2: Department of Artificial Organ, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan 3: Department of Therapeutic Strategy for Heart Failure, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan 4: Department of Cardiovascular Surgery, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku, Tokyo, 162-8666, Japan 5: Department of Cardiothoracic Surgery, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan

Publication date: 2011-09-01

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• In this Subject: Medicine (General) ,  Public Health ,  Surgery
• By this author: Ando, Masahiko ;  Takewa, Yoshiaki ;  Nishimura, Takashi ;  Yamazaki, Kenji ;  Kyo, Shunei ;  Ono, Minoru ;  Tsukiya, Tomonori ;  Mizuno, Toshihide ;  Taenaka, Yoshiyuki ;  Tatsumi, Eisuke

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