Hernia disease and collagen gene regulation: are there clues for intervention?

Authors: Lynen Jansen, Petra; Klinge, Uwe; Mertens, Peter

Source: Hernia, Volume 10, Number 6, December 2006 , pp. 486-491(6)

Publisher: Springer

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Abstract:

Collagens belong to the most abundant proteins in the body. After tissue injury, a coordinated regulation of collagen gene expression guides the formation of a provisional matrix that subsequently evolves into a mature scar with tensile strength. In the following, knowledge regarding collagen gene regulation that may provide insight into how to specifically address the biological problem of soft tissue weakness and recurrent hernia disease is summarized.

Keywords: Collagen expression; Synthesis; Gene regulation; Transcription

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s10029-006-0147-6

Affiliations: 1: Email: plynen@ukaachen.de

Publication date: 2006-12-01