RNA interference: on the road to an alternate therapeutic strategy!

Authors: Dave R.S.; Pomerantz R.J.

Source: Reviews in Medical Virology, Volume 13, Number 6, November 2003 , pp. 373-385(13)

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Abstract:

RNA interference (RNAi) is a newly described natural biological phenomenon mediated by small interfering RNA (siRNA) molecules which target viral mRNA for degradation by cellular enzymes. RNAi has become a method of choice for studying gene function, especially in mammalian systems. With proof-of-concept studies already presented against a wide variety of human pathogens and several innovative methods of delivering the siRNA to a wide variety of primary cells available, the role for siRNA as a potential therapeutic strategy is becoming increasingly clear. This review presents recent advances in this direction. Copyright © 2003 John Wiley & Sons, Ltd.

Document Type: Review article

DOI: http://dx.doi.org/10.1002/rmv.407

Affiliations: 1: Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA

Publication date: 2003-11-01

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