CMV and blood transfusions

Author: Roback J.D.^{1, *}

Source: Reviews in Medical Virology, Volume 12, Number 4, July/August 2002 , pp. 211-219(9)

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Abstract:

Among the human herpesviruses, cytomegalovirus (CMV) is the only one that has assumed significant importance in blood transfusion. Transfusion transmission of CMV (TT-CMV) to seronegative immunocompromised patients can lead to lethal CMV disease. Studies over the past 30 years have demonstrated that monocytes latently infected with CMV represent the primary vector for TT-CMV, and that TT-CMV can be largely abrogated by transfusing at-risk patients with either seronegative units or blood filtered to remove white blood cells. However, the small number of cases of breakthrough TT-CMV that follow transfusion of either seronegative or filtered blood still produce morbidity and mortality. These circumstances have motivated ongoing efforts to provide improved protection from TT-CMV, including the use of CMV DNA amplification for blood screening, and pathogen inactivation to sterilise all blood components prior to transfusion. Copyright © 2002 John Wiley & Sons, Ltd.

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.1002/rmv.353

Affiliations: 1: *

Publication date: 2002-07-01

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