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Identification of new limonoids from Swietenia and their biological activity against insects

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BACKGROUND: Natural limonoids are one group of compounds being studied for their insecticidal properties. To discover new limonoids with better activities, analogs were prepared via acylation and hydrolysis, and bioassayed.

RESULTS: Analogs were identified using one‐ and two‐dimensional (COSY, HMQC and HMBC) 1H and 13C NMR, IR and MS. 3‐O‐Isovalerylswietenolide (13) and 3‐O‐isobutyrylswietenolide (14) showed excellent antifeedant activity, with DC50 values of 0.19 and 0.009 mg L−1 respectively, compared with the natural limonoid swietenolide (80.6 mg L−1) against fourth‐instar Spodoptera frugiperda (JE Smith) larvae.

CONCLUSION: This work shows that limonoid analogs prepared through semi‐synthesis can be used as lead compounds for the development of new insecticides. Copyright © 2010 Society of Chemical Industry

Keywords: antifeedant; insecticides; limonoids; semi‐synthesis

Document Type: Research Article


Publication date: December 1, 2010

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