Skip to main content

Identification of new limonoids from Swietenia and their biological activity against insects

The full text article is not available for purchase.

The publisher only permits individual articles to be downloaded by subscribers.


BACKGROUND: Natural limonoids are one group of compounds being studied for their insecticidal properties. To discover new limonoids with better activities, analogs were prepared via acylation and hydrolysis, and bioassayed.

RESULTS: Analogs were identified using one‐ and two‐dimensional (COSY, HMQC and HMBC) 1H and 13C NMR, IR and MS. 3‐O‐Isovalerylswietenolide (13) and 3‐O‐isobutyrylswietenolide (14) showed excellent antifeedant activity, with DC50 values of 0.19 and 0.009 mg L−1 respectively, compared with the natural limonoid swietenolide (80.6 mg L−1) against fourth‐instar Spodoptera frugiperda (JE Smith) larvae.

CONCLUSION: This work shows that limonoid analogs prepared through semi‐synthesis can be used as lead compounds for the development of new insecticides. Copyright © 2010 Society of Chemical Industry

Keywords: antifeedant; insecticides; limonoids; semi‐synthesis

Document Type: Research Article


Publication date: December 1, 2010

More about this publication?

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Partial Open Access Content
Partial Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more