Identification of new limonoids from Swietenia and their biological activity against insects
Authors: Fowles, Robert; Mootoo, Baldwin; Ramsewak, Russel; Khan, Ayub; Ramsubhag, Adesh; Reynolds, William; Nair, Muraleedharan
Source: Pest Management Science, Volume 66, Number 12, December 2010 , pp. 1298-1303(6)
Publisher: John Wiley & Sons, Ltd.
Abstract:BACKGROUND: Natural limonoids are one group of compounds being studied for their insecticidal properties. To discover new limonoids with better activities, analogs were prepared via acylation and hydrolysis, and bioassayed.
RESULTS: Analogs were identified using one‐ and two‐dimensional (COSY, HMQC and HMBC) 1H and 13C NMR, IR and MS. 3‐O‐Isovalerylswietenolide (13) and 3‐O‐isobutyrylswietenolide (14) showed excellent antifeedant activity, with DC50 values of 0.19 and 0.009 mg L−1 respectively, compared with the natural limonoid swietenolide (80.6 mg L−1) against fourth‐instar Spodoptera frugiperda (JE Smith) larvae.
CONCLUSION: This work shows that limonoid analogs prepared through semi‐synthesis can be used as lead compounds for the development of new insecticides. Copyright © 2010 Society of Chemical Industry
Document Type: Research Article
Publication date: December 1, 2010