Authors: Sowter H.M.¹; Ferguson M.²; Pym C.³; Watson P.⁴; Fox S.B.²; Han C.⁵; Harris A.L.¹

Source: The Journal of Pathology, Volume 201, Number 4, December 2003 , pp. 573-580(8)

Publisher: John Wiley & Sons, Ltd.

Abstract:

Ductal carcinoma in situ (DCIS) of the breast is an early, non-invasive lesion and the prognosis is associated with the extent of necrosis and cell death within the tumour. Two cell death genes, BNip3 and NIX, are up-regulated in response to hypoxia in breast carcinoma cells, although any involvement of either gene in disease progression is currently unknown. This study has analysed the expression of BNip3 and NIX in 56 samples of breast DCIS, as well as in adjacent benign and invasive breast tissue. Both genes are strongly expressed in the epithelial component of a subset of DCIS and invasive disease. The data show a correlation between high expression of BNip3 in the DCIS cells and a high-grade, necrotic lesion that is likely to be associated with invasive tumour. BNip3 was present in tumour-associated macrophages and in apocrine metaplastic lesions. Expression of NIX did not correlate with any of the parameters investigated Copyright © 2003 John Wiley & Sons, Ltd.

Keywords: BNip3; hypoxia; ductal carcinoma in situ of the breast; necrosis; cell death

Document Type: Research article

DOI: http://dx.doi.org/10.1002/path.1486

Affiliations: 1: Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DS, UK 2: Nuffield Department of Clinical Laboratory Science, John Radcliffe Hospital, Oxford, UK 3: Department of Histopathology, John Radcliffe Hospital, Oxford, UK 4: University of Manitoba, Winnipeg, Manitoba, Canada R3E OW3 5: Department of Statistics, Churchill Hospital, Oxford, UK

Publication date: 2003-12-01

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