Not just angiogenesis—wider roles for the angiopoietins

Author: Jones P.F.¹

Source: The Journal of Pathology, Volume 201, Number 4, December 2003 , pp. 515-527(13)

Publisher: John Wiley & Sons, Ltd.

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Abstract:

Since the discovery of the angiopoietins, much interest has been focused on their biological actions and their potential use as therapeutic targets. It is generally accepted that the angiopoietins play an important role in angiogenesis and hence are described as angiogenic factors. However, it is becoming increasingly clear that this is not their only role and it is likely that the angiopoietins have important roles in a wider range of biological and pathological functions. Copyright © 2003 John Wiley & Sons, Ltd.

Keywords: angiopoietins; Tie2; angiogenesis; endothelium

Document Type: Review article

DOI: 10.1002/path.1452

Affiliations: 1: Molecular Medicine Unit, University of Leeds, Clinical Sciences Building, St James's University Hospital, Leeds LS9 7TF, UK

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