IngentaConnect Opioid activity of Humana formula for newborns

Authors: Jarmołowska, Beata; Szłapka-Sienkiewicz, Edyta; Kostyra, Elżbieta; Kostyra, Henryk; Mierzejewska, Dagmara; Marcinkiewicz-Darmochwał, Katarzyna

Source: Journal of the Science of Food and Agriculture, Volume 87, Number 12, September 2007 , pp. 2247-2250(4)

Publisher: John Wiley & Sons, Ltd.

Abstract:

Recent investigations have suggested that novel food should be evaluated not only from the nutritional but also from the physiological point of view. Opioid peptides derived from milk belong to compounds whose physiological importance has not yet been fully recognized. The commercial Humana formula for newborns sold on the Polish market was assayed in the study. Four opioid peptides with agonistic and antagonistic activity were found in a peptide extract from the Humana formula and its pepsin-trypsin hydrolysate: β-casomorphin-5, casoxin C and 6 and lactoferroxin A. The opioid activity of the peptide extracts was determined by examining their influence on the motor activity of isolated rabbit intestine. In conclusion, it was suggested that the opioid activity of the formulas could be an additional indicator of their diversity. Copyright © 2007 Society of Chemical Industry

Keywords: β-casomorphins; opioid activity; milk formula; motor activity; intestine

Document Type: Research article

DOI: 10.1002/jsfa.2951

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