IngentaConnect Hypoglycemic effect of extract of Hericium erinaceus

Authors: Jinn Chyi Wang¹; Shu Hui Hu²; Jih Terng Wang¹; Ker Shaw Chen¹; Yi Chen Chia¹

Source: Journal of the Science of Food and Agriculture, Volume 85, Number 4, March 2005 , pp. 641-646(6)

Abstract:

Recent studies have determined that many types of mushroom (eg Hericium spp), may have important physiological functions in humans, including antioxidant activities, the regulation of blood lipid levels and reduction of blood glucose levels. In this study, a methanol extract of the fruiting bodies of Hericium erinaceus was adsorbed on silica gel columns and eluted using polarity gradients of chloroform/ethyl acetate/acetone/methanol. The major components of the extract were D-threitol, D-arabinitol and palmitic acid identified by their chromatographic profiles and spectroscopic characteristics. The methanol extract of H erinaceus was concentrated to remove solvent yielding a residue (referred to as HEM) which was added to the diet. The hypoglycemic effects of feeding HEM to streptozotocin-induced diabetic rats were studied. Polydipsia was stronger in induced diabetic rats not fed HEM than in those receiving HEM. Rats fed with HEM had significantly lower elevation rates of blood glucose level than those not fed with HEM. The effects on blood glucose, serum triglyceride and total cholesterol levels were more significant in the rats fed daily with HEM at doses of 100 mg kg^-1 body weight (bw) rather than 20 mg kg^-1 bw (p < 0.05). Copyright © 2004 Society of Chemical Industry

Keywords: hypoglycemic effect; induced-diabetic; extracts; Hericium erinaceus

Document Type: Research article

DOI: 10.1002/jsfa.1928

Affiliations: 1: Department of Food Science and Technology, Tajen Institute of Technology, Ping Tung, Taiwan 2: Department of Technology for Medical Science, Kaohsiung Medical University, Kaohsiung, Taiwan

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