IngentaConnect Bioactivity of falcarinol and its content in carrots

Authors: Hansen S.L.¹; Purup S.²; Christensen L.P.¹

Source: Journal of the Science of Food and Agriculture, Volume 83, Number 10, August 2003 , pp. 1010-1017(8)

Abstract:

The concentration-dependent activity of the polyacetylene falcarinol ((9Z)-heptadeca-1,9-dien-4,6-diyn-3-ol), isolated from carrots, was investigated in a bioassay with primary mammary epithelial cells in collagen gels and compared with that of beta

-carotene, the orange pigment in carrots. Falcarinol showed biphasic activity, having stimulatory effects between 0.01 and 0.05 µg ml^-1 and inhibitory effects between 1 and 10 µg ml^-1, whereas beta

-carotene showed no effect in the concentration range 0.001–100 µg ml^-1. The results are discussed in relation to the health-promoting effects of carrots and related vegetables. Falcarinol was quantified in the carrot cultivars Bolero, Rodelika and Fancy by analytical reverse phase HPLC, subjected to various processing and storage conditions in order to study how long-term storage, blanching, freezing and boiling influence the content of falcarinol. Long-term storage of raw carrot cubes (1 cm³) reduced the falcarinol content by almost 35%. A similar reduction was found in steam-blanched carrot cubes (1 cm³). Long-term storage at -24 °C of steam blanched carrot cubes did not reduce the falcarinol content further. A reduction of almost 70% in the falcarinol content was found in carrot pieces boiled in water for 12 min compared with raw carrots. Copyright © 2003 Society of Chemical Industry

Keywords: Daucus carota; falcarinol; polyacetylene; bioactivity; bioassay; epithelial cells; long-term storage; processing

Document Type: Research article

DOI: 10.1002/jsfa.1442

Affiliations: 1: Department of Horticulture, Danish Institute of Agricultural Sciences, Research Centre Aarslev, Kirstinebjergvej 10, DK-5792 Aarslev, Denmark 2: Department of Animal Nutrition and Physiology, Danish Institute of Agricultural Sciences, Research Centre Foulum, DK-8830 Tjele, Denmark

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