Authors: Sirisansaneeyakul, Sarote; Chainoy, Rittikorn; Vanichsriratana, Wirat; Srinophakun, Thongchai; Chisti, Yusuf

Source: Journal of Chemical Technology & Biotechnology, Volume 84, Number 8, August 2009 , pp. 1218-1228(11)

Publisher: John Wiley & Sons, Ltd.

Abstract:

BACKGROUND: Liquid emulsion membrane (LEM)-encapsulated live cells can be used to produce various products. This work reports on LEM-encapsulated cells for producing xylitol and models the production process.

RESULTS: Encapsulated cells of Candida mogii ATCC 18364 were used to produce xylitol from xylose. Soybean oil LEM consisting of 5% (w/v) lanolin and microwaxes was found most suitable for this process. The LEM-encapsulated cells were immobilized in a tubular biocatalytic loop. Xylitol was produced under oxygen-limited and aerobic conditions. Xylitol productivity and yield were 0.005 g L⁻¹ h⁻¹ and 0.52 g g⁻¹, respectively, for oxygen-limited operation. Under aerobic conditions, xylitol productivity increased greatly to 0.022 g L⁻¹ h⁻¹, but yield on xylose declined to 0.49 g g⁻¹. A mathematical model successfully described substrate consumption and product formation in the LEM-immobilized cell system.

CONCLUSION: Potentially, immobilized cell LEM systems are useful for certain fermentations and they can be successfully modeled, as shown by the example of xylitol from xylose process. Copyright © 2009 Society of Chemical Industry

Keywords: xylitol; xylose; liquid emulsion membrane; cell encapsulation; Candida mogii

Document Type: Research article

DOI: http://dx.doi.org/10.1002/jctb.2161

Publication date: 2009-08-01

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