IngentaConnect Protein name tagging guidelines: lessons learned

Authors: Mani Inderjeet¹; Hu Zhangzhi¹; Jang Seok Bae¹; Samuel Ken²; Krause Matthew¹; Phillips Jon¹; Wu Cathy H.¹

Source: Comparative and Functional Genomics, Volume 6, Numbers 1-2, February 2005 , pp. 72-76(5)

Abstract:

Interest in information extraction from the biomedical literature is motivated by the need to speed up the creation of structured databases representing the latest scientific knowledge about specific objects, such as proteins and genes. This paper addresses the issue of a lack of standard definition of the problem of protein name tagging. We describe the lessons learned in developing a set of guidelines and present the first set of inter-coder results, viewed as an upper bound on system performance. Problems coders face include: (a) the ambiguity of names that can refer to either genes or proteins; (b) the difficulty of getting the exact extents of long protein names; and (c) the complexity of the guidelines. These problems have been addressed in two ways: (a) defining the tagging targets as protein named entities used in the literature to describe proteins or protein-associated or -related objects, such as domains, pathways, expression or genes, and (b) using two types of tags, protein tags and long-form tags, with the latter being used to optionally extend the boundaries of the protein tag when the name boundary is difficult to determine. Inter-coder consistency across three annotators on protein tags on 300 MEDLINE abstracts is 0.868 F-measure. The guidelines and annotated datasets, along with automatic tools, are available for research use. Copyright © 2005 John Wiley & Sons, Ltd.

Keywords: nomenclature; protein names; guidelines; database curation; named entity tagging; inter-coder reliability

Document Type: Miscellaneous

DOI: 10.1002/cfg.452

Affiliations: 1: Georgetown University, 37th and O Streets NW, Washington, DC 20057, USA 2: The MITRE Corporation, 7515 Colshire Drive, McLean, VA 22102, USA

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