Randomized clinical trial of granisetron, droperidol and metoclopramide for the treatment of nausea and vomiting after laparoscopic cholecystectomy

Authors: Fujii Y.; Tanaka H.; Kawasaki T.

Source: British Journal of Surgery, Volume 87, Number 3, March 2000 , pp. 285-288(4)

Buy & download fulltext article:

The full text article is not available for purchase.

The publisher only permits individual articles to be downloaded by subscribers.

Abstract:

Summary

Background: Patients undergoing laparoscopic cholecystectomy (LC) may be especially at risk of experiencing postoperative nausea and vomiting (PONV). This study was undertaken to evaluate the efficacy of granisetron, droperidol and metoclopramide for the treatment of PONV after LC.

Methods: After experiencing PONV during the first 3 h after recovery from anaesthesia, 120 patients (78 women) received, in a randomized double-blind manner, granisetron 40 g/kg, droperidol 20 g/kg or metoclopramide 0·2 mg/kg (n = 40 per group) intravenously. Patients were then observed for 24 h after administration of the study drug.

Results: Complete control of established PONV, defined as no emetic symptoms and no need for another rescue antiemetic medication, was achieved in 88 per cent of patients with granisetron, 60 per cent with droperidol and 55 per cent with metoclopramide (P < 0·05). No clinically adverse events were observed in any of the groups.

Conclusion: A high dose of granisetron (40 g/kg) was more effective than droperidol 20 g/kg or metoclopramide 0·2 mg/kg for the treatment of established PONV after LC.

Language: English

Document Type: Miscellaneous

Publication date: 2000-03-01

More about this publication?

As of January 2010, this journal will no longer be available on IngentaConnect, please visit Wiley InterScience to arrange continued access to this content
Access this journal at Wiley InterScience
ingentaconnect is not responsible for the content or availability of external websites