Evaluation of Solitary Pulmonary Nodule in Human Immunodeficiency Virus Infected Patients

The full text article is temporarily unavailable.

We apologise for the inconvenience. Please try again later.


BACKGROUND: While the etiologies of solitary pulmonary nodules (SPNs) in immunocompetent patients are well established, common etiology, diagnostic techniques, and guidelines to assess SPNs in patients infected with human immunodeficiency virus (HIV) have not been established. OBJECTIVE: To define the etiology of SPN in HIV-infected patients and to examine efficacy of diagnostic testing for SPN. METHODS: We performed a retrospective chart review of HIV-infected patients admitted to a designated acquired immune deficiency syndrome (AIDS) center. Microbiological and histopathological specimens from sputum, bronchoalveolar lavage, and biopsies were analyzed. Charts were fully analyzed from time of admission until definitive diagnosis or loss to follow-up. RESULTS: During the 10-year observational period, 10 of 5,000 HIV-infected patients admitted to the hospital were diagnosed with SPN via chest radiography or computed tomography (CT). Among these 10 patients, 6 had a definitive diagnosis. Underlying etiologies included infection (5/10) and lung adenocarcinoma (1/10); none were identified in the remaining 4 subjects. Sputum analysis provided no diagnostic value in discovering pathogenesis in any of these cases. Fiberoptic bronchoscopy with bronchoalveolar lavage and transbronchial biopsy were diagnostic in 3 cases, while CT-guided percutaneous transthoracic needle biopsy (PTNB) was diagnostic in 2 cases. One patient required open lung biopsy. CONCLUSIONS: Etiologies of SPN in HIV-infected patients are varied and difficult to diagnose. In our study, SPN was attributable to infectious etiology in 50% of cases. Sputum analysis was of no diagnostic value. Biopsy is necessary for definitive diagnosis and treatment.

Keywords: HIV infection; acquired immune deficiency syndrome; diagnostic lung testing; human immunodeficiency virus; pulmonary nodule

Document Type: Research Article

DOI: http://dx.doi.org/10.4187/respcare.01377

Affiliations: Department of Internal Medicine, St Barnabas Hospital, Bronx, New York, USA

Publication date: July 1, 2012

Related content

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more