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Inhaled Nitric Oxide as Salvage Therapy in Massive Pulmonary Embolism: A Case Series

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Abstract:

Inhaled nitric oxide (INO) has been shown to preferentially lower resistance in the pulmonary vasculature. The relative selectiveness of INO in accomplishing this effect makes it an attractive drug to administer as salvage therapy in patients with acute right ventricular failure secondary to pulmonary embolism. We describe 4 cases in which INO was used as a temporizing agent to decrease right ventricular after-load following massive near-fatal pulmonary embolism. All 4 patients survived to hospital discharge.

Keywords: acute cor pulmonale; inhaled nitric oxide; massive pulmonary embolism; right heart failure

Document Type: Research Article

DOI: http://dx.doi.org/10.4187/respcare.01373

Publication date: March 1, 2012

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