Successful Extracorporeal Membrane Oxygenation for Respiratory Failure in an Infant With DiGeorge Anomaly, Following Thymus Transplantation

The full text article is not available for purchase.

The publisher only permits individual articles to be downloaded by subscribers.


We report the first successful use of venovenous extracorporeal membrane oxygenation (ECMO) for refractory respiratory failure in an infant with DiGeorge anomaly, following thymus transplantation. A 23-month-old female with complete immune-incompetent DiGeorge anomaly 65 days after allogenic thymus transplantation was treated in our pediatric intensive care unit for acute respiratory failure secondary to bacterial sepsis. She subsequently developed acute hypercarbic respiratory failure unresponsive to conventional medical therapy. She was successfully managed with venovenous ECMO for 4 days, with complete resolution of her respiratory symptoms. This case demonstrates the complex decision making process regarding initiation of ECMO in patients with severe immunodeficiency.

Keywords: DiGeorge anomaly; ECMO; extracorporeal membrane oxygenation; hypercarbia; immunodeficiency; mechanical ventilation; pediatric; respiratory failure; sepsis

Document Type: Research Article


Affiliations: Division of Pediatric Critical Care Medicine, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA

Publication date: June 1, 2011

More about this publication?
Related content



Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more