Cardiac Response and N-Terminal-Pro-Brain Natriuretic Peptide Kinetics During Exercise in Patients With COPD

Authors: Wang, Hao-Yan; Xu, Qiu-Fen; Xiao, Yao; Zhang, Jian; Sperry, Al

Source: Respiratory Care, Volume 56, Number 6, June 2011 , pp. 796-799(4)

Publisher: The Journal Respiratory Care Company

Buy & download fulltext article:

The full text article is not available for purchase.

The publisher only permits individual articles to be downloaded by subscribers.


BACKGROUND: COPD increases the risk of cardiovascular problems. Dyspnea on exertion can be associated with COPD or heart failure or both. N-terminal-pro-brain natriuretic peptide (NT-pro-BNP) is a marker of cardiac dysfunction, and exercise testing can identify subtle heart abnormalities. OBJECTIVE: To determine whether cardiac dysfunction adds to the mechanism of dyspnea caused primarily by impaired lung function in patients with mild to moderate COPD. METHODS: With 19 COPD patients and 10 healthy control subjects we measured physiologic variables and collected venous blood samples before and during incremental and constant-work-rate exercise, and measured NT-pro-BNP. RESULTS: Peak oxygen uptake and constant-work exercise time were significantly lower in the COPD group than in the control group (16 ± 4 mL/min/kg vs 19 ± 6 mL/min/kg, P = .04, and 7.8 ± 6.5 min vs 14.8 ± 7.3 min, P = .02). Between the groups there were no significant differences in anaerobic threshold, oxygen pulse (oxygen uptake divided by heart rate), or heart-rate reserve (difference between predicted and measured maximum heart rate). Both at rest and during constant-work exercise, NT-pro-BNP was not significantly higher in the COPD group than in the control group. In the COPD patients there was no significant correlation between constant-work exercise time and NT-pro-BNP at rest or during exercise. CONCLUSIONS: Heart failure did not contribute to exercise intolerance in patients with mild to moderate COPD.

Keywords: Brain natriuretic peptide; COPD; N-terminal-pro-BNP; cardiac; cardiac response; chronic; disease; dyspnea; exercise; exertion; heart failure; obstructive; pulmonary

Document Type: Research Article


Affiliations: Department of Respiratory Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, China

Publication date: June 1, 2011

More about this publication?
Related content



Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content

Text size:

A | A | A | A
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages. print icon Print this page