Mechanisms of Functional Loss in Patients With Chronic Lung Disease
Author: MacIntyre, Neil R.
Source: Respiratory Care, Volume 53, Number 9, September 2008 , pp. 1177-1184(8)
Publisher: The Journal Respiratory Care Company
Abstract:Functional loss (often quantified as exercise limitation) is common in patients with chronic lung disease. The factors involved are multiple and many may be present together in a given patient. Ventilatory factors involve an imbalance in load/capacity relationships. Specifically, breathing loads from abnormal respiratory-system mechanics and/or excessive ventilatory demand cannot be handled by respiratory muscles that are dysfunctional or malpositioned. Gas-exchange factors involve impaired ventilation-perfusion relationships that lead to hypoxemia, impaired oxygen delivery, and pulmonary hypertension. Cardiovascular factors involve coexisting intrinsic heart disease, right-ventricular overload from pulmonary vascular abnormalities, and simple deconditioning. Skeletal muscle (both respiratory and limb) factors involve direct inflammatory mediator effects on muscle function, malnutrition, blood-gas abnormalities, compromised oxygen delivery from right-heart dysfunction, electrolyte imbalances, drugs, and comorbid states. Other less well understood factors include excessive dyspnea, impaired motivation, orthopedic issues, and psychiatric issues.
Document Type: Research article
Publication date: 2008-09-01
- As of January 1, 2013, Respiratory Care content will no longer be hosted on ingentaconnect. Please contact the publisher at firstname.lastname@example.org for information on how to continue access to this title.
- Editorial Board
- Information for Authors
- Submit a Paper
- Subscribe to this Title
- Membership Information
- Information for Advertisers
- Clinical Practice Guidelines
- Past OPEN FORUM Abstracts
- ingentaconnect is not responsible for the content or availability of external websites